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AASLD 2024: Tune Therapeutics Shows Near-Complete HepB Virus Repression with Tune-401 Epigenetic Silencer

AASLD 2024: Tune Therapeutics Shows Near-Complete HepB Virus Repression with Tune-401 Epigenetic Silencer

DURHAM, N.C. & SEATTLE--November 19, 2024--Leading epigenome editing company Tune Therapeutics showcased new data yesterday at the American Association for the Study of Liver Diseases (AASLD) conference, in support of its drive to develop a lasting, functional cure for chronic Hepatitis B Virus (HBV).

Tune unveiled its lead HBV program at the 2023 AASLD event with preclinical data showing strong and durable effect in targeted human hepatocytes. This year, Tune Therapeutics Principal Scientist Brian Cosgrove shared new in vitro and in vivo data, showcasing Tune’s clinically optimized liver-targeting LNP-RNA epi-silencing drug (Tune-401) – which enabled the near-complete repression of HBV RNA in human cells, and in a ‘true infection’ FRG mouse model.

Tune Therapeutics / Uncategorized - 11/19/2024

Pappas Capital Announces the Passing of Senior Venture Partner Dr. Ernest Mario

RESEARCH TRIANGLE PARK, N.C., Oct. 21, 2024 -- It is with deep sadness that Pappas Capital announces the passing of Dr. Ernest Mario, Senior Venture Partner and one of the founders of Pappas’ venture capital business. Ernie joined Pappas Capital in 2002 as a member of the firm’s Scientific Advisory Board, becoming a Senior Venture Partner in 2011. He helped to build Pappas Capital into a leading life science venture capital firm and was a friend and mentor to the entire Pappas team. His counsel and legacy will always remain with us.

Uncategorized - 10/21/2024

BioAtla Announces Clinical Collaboration with Bristol Myers Squibb to Study Treatments for Solid Tumors

SAN DIEGO, Jan. 10, 2022 -- BioAtla, Inc. (Nasdaq: BCAB), a global clinical-stage biotechnology company focused on the development of Conditionally Active Biologic (CAB) antibody therapeutics, today announced that it has entered into a clinical collaboration with Bristol Myers Squibb (NYSE: BMY) to investigate BioAtla's two lead CAB-ADC candidates, BA3011 and BA3021, in combination with Bristol Myers Squibb's anti-PD-1 therapy Opdivo® (nivolumab).

Under the terms of the agreement, BioAtla and Bristol Myers Squibb will collaborate on clinical trials of separate combination therapies using two of BioAtla's Conditionally Active Biologic Antibody Drug Conjugates, BA3011 and BA3021, each in combination with Opdvio. BioAtla will serve as the study sponsor and will be responsible for costs associated with the trial execution. Bristol Myers Squibb will provide Opdivo clinical drug supply for the study.

BioAtla / Uncategorized - 01/10/2022

Pappas, Chiesi Venture Fund Joins Ranks of Pharma & VC Partnerships

 
Pappas, Chiesi Venture Fund Joins Ranks of Pharma & VC Partnerships

Art Pappas has overseen his own firm’s venture capital investments for 20 years. Now the veteran life sciences investor is adding on a new role, scoping out investment opportunities for a pharmaceutical company’s new venture fund.

Italian pharma Chiesi Group’s recently-launched Chiesi Ventures will focus on investing in companies developing treatments for rare and orphan diseases. The bulk of the money for investments will come from Chiesi, but the fund will be managed by Durham, NC-based A.M. Pappas & Associates, whose own investing unit, Pappas Ventures, has backed numerous companies that have found exits via acquisition or initial public offering.

Chiesi Ventures / Uncategorized - 09/10/2014

Chiesi Launches Venture Capital Fund via Strategic Collaboration with A. M. Pappas & Associates

Chiesi Launches Venture Capital Fund via Strategic Collaboration with A. M. Pappas & Associates

Strategic Collaboration to Focus on Rare Disease Early Stage Investment Opportunities

PARMA, Italy and RESEARCH TRIANGLE PARK, North Carolina, September 2, 2014 /PRNewswire/ -- The Chiesi Group announced today the launch of its venture capital fund, Chiesi Ventures, via a strategic collaboration with A. M. Pappas & Associates.

Chiesi Ventures will complement the strategic interest of the Chiesi Group in the area of rare diseases by investing in early stage opportunities and expanding the Chiesi network in the US among universities, venture capital investors, rare disease patient organizations and entrepreneurial companies developing treatments for rare diseases.

Chiesi Ventures / Uncategorized - 09/02/2014

MUSC Foundation for Research Development welcomes Art Pappas to board

Pappas to share venture capital expertise in pharmaceutical and life sciences industries

CHARLESTON, SC - April 23, 2014 - The Medical University of South Carolina Foundation for Research Development (FRD) has announced that venture capitalist Art Pappas has joined the organization’s Board of Directors, effective immediately.

Uncategorized - 04/23/2014

Pappas Ventures Promotes Scott Weiner to Partner

RESEARCH TRIANGLE PARK, N.C., Jan. 8, 2014 /PRNewswire/ -- Pappas Ventures, a life science venture capital firm, announced today that Scott Weiner, who joined the firm in 2006, has been promoted to Partner.

"We are pleased to recognize Scott's many contributions to the development and success of our firm," said Art Pappas, Managing Partner at Pappas Ventures. "His knowledge of the life sciences industry and broad transaction experience is valued immensely both by my Pappas colleagues and by our many portfolio companies."

Among the many Pappas Ventures portfolio companies with which Mr. Weiner has been involved, he played a key role in the firm's successful investments in TESARO, Achillion Pharmaceuticals and Athersys. He currently serves as a director for Gentis and Milestone Pharmaceuticals, and as an observer for IlluminOss Medical, Liquidia Technologies and Thrasos Therapeutics.

Uncategorized - 01/08/2014

Pappas Ventures Names Franz B. Humer as Venture Partner and Senior Advisor

RESEARCH TRIANGLE PARK, N.C., Dec. 10, 2013 /PRNewswire/ -- Pappas Ventures, a life science venture capital firm, announced today the appointment of Franz B. Humer as a Venture Partner and Senior Advisor with the firm. Dr. Humer is currently the Chairman of Roche Holding Ltd, a position he will retire from in March 2014.

Dr. Humer brings a wealth of leadership experience from the pharmaceutical and life science industry, including a transformative 15-year tenure as Chairman and/or Chief Executive Officer of Roche. He previously served as Chief Operating Officer and Head of Pharmaceuticals for F. Hoffmann-La Roche Ltd.

Uncategorized - 12/10/2013
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